The final stage has the characteristics of destructive lesions of the skin and bone, occurring in 10-20% of patients who do not get treatment, usually appears after 5 years or more after infection. No congenital transmission and infection rarely occurs, and if it happens it is usually fatal infection, and cause disability. Unlike the infection by syphilis, yaws did not attack the brain, eyes, aorta or the tools on the abdomen.
The disease is caused by Treponema pallidum, subspecies pertenue from spirochaeta. Yaws particularly affects children living in rural tropical hot, humid, more often found in men. Global prevalence of yaws declined dramatically after treatment with penicillin campaign en masse in the 1950s and the 1960s, but yaws disease reappeared in most of western equatorial Africa and the spread of the infection remains in the focus of Latin America, Caribbean islands, India, Asia Southeast and Islands South Pacific.
Yaws transmitted by direct contact with exudate in the early lesions of the skin of people exposed to infection. Indirect transmission through contamination from scratch, the goods are in contact with skin and possibly also by flies that settle on an open wound, but this is uncertain. Temperature also affects the
morphology, distribution and infection rates of early lesions. Incubation period: From 2 to 3 weeks. Time of transmission: The transmission varies and can extend that appear intermittently for several years barupa wet lesions. The bacteria that cause infections are not usually found in end-stage destructive lesions.
To protect a country from the risk of reinfection that is doing the active mass treatment program for the community, the neighboring countries in the near-endemic areas should do some research to find a way suitable for the treatment of disease yaws. Against people who moved through the state border, surveillance needs to be done.