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Chinaberry - Melia azedarach L

Chinaberry - Melia azedarach L is a plant that has synonyms: M. Azadirachta L., M. dubia auct. (Non. Cav.) How et T. Chen, M. dubia Cav., M. G. japonica Don., M. toosendan Sieb.et Zucc. And included in the familia: Meliaceae

Chinaberry - Melia azedarach L usually planted on the side of the road as a shade tree, sometimes growing wild in the area near the beach. Trees are growing faster and are of Chinese origin can be found from the lowlands to the mountains with an altitude of 1,100 m above sea level. This many-branched tree has bark dark brown, with a height of up to 4 m. The leaves are compound, alternate with long growing 20-80 cm. Leaf shape is oval, serrated edge, pointed tip, base rounded or obtuse, the upper surface of leaves of dark green, light green bottom, 3-7 cm long, 1.5 to 3 cm wide. Compound interest length 10-20 cm, out of the armpit leaves. Consist of 5 petals, about 1 cm long, pale purple color, and smell nice. Fruit round, about 1.5 cm in diameter. Seeds are highly toxic and is used to poison fish or insects.


Composition of Chinaberry - Melia azedarach L:

Bark and root bark contains toosendanin (C30H38O11) and components yang.larut (C30H40O12). In addition, there are also alkaloids azaridine (margosina), kaempferol, resin, tannin, n-triacontane, ß-sitosterol, and triterpene kulinone. Root bark less toxic, than the bark. Seeds contain highly toxic resin, 60% fatty oil consisting of stearic acid, palmitic, oleic, linoleic, lauric, valerianat, butyrate, and a small amount of essential oil sulfur. Fruits contain sterols, catechol, vanilat acid. Leaves, paraisina contains alkaloids, flavonoids routine, bitter substances, saponins, tannins, steroida, and kaempferol.

Curable Disease with Chinaberry - Melia azedarach L:

Root bark and bark from Chinaberry - Melia azedarach L bitter, cold nature, slightly poisonous (toxic). Chinaberry - Melia azedarach L entered meridian liver, stomach, and spleen. Efficacious cleaning hot and humid, diuretics, laxatives, vomiting stimulants, and kills intestinal worms. Fruits of Chinaberry - Melia azedarach L bitter, cold nature, less toxic. Chinaberry - Melia azedarach L activate the life energy to relieve pain, and as a topical, efficacious antifungals. Leaves efficacious diuretic and kills intestinal worms. Whole nutritious plant insect killer.


Pharmacological effects and outcomes research: 

Toosendanin an active component of Chinaberry - Melia azedarach L, which merit antelmintik and working longer than santonin. In in vitro experiments, infusion Meliae Cortex by 25 - 50% cause paralysis pinworms from rats. Giving toosendanin 8 mg / kg in mice intravenously (IV) or intramuscular (IM) or injections of 0.4 mg / kg directly into the respiratory centers in the medulla, causing respiratory failure. This indicates toosendanin can cause respiratory depression.

Note:

Substance toosendanin on Chinaberry - Melia azedarach L, rarely cause side effects. But sometimes it can cause symptoms of dizziness, nausea, vomiting, abdominal pain, diarrhea, reddening of the face (flushing), and somnolence. In some patients it can cause blurred vision and itchy. These symptoms will disappear by itself in 2-3 hours, and in some patients may be longer than one day. These symptoms will recover spontaneously without specific treatment. As a laxative intestinal worms, toosendanin fewer side effects than piperasin citrate and santonin. Severe side effects arise when the dose exceeds 0.8 mg extract in adults.
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