Platelets have a primary function to freeze the blood, so much blood was wasted when there is bleeding. University of Munich revealed that platelets also serve to boost the immune response. That is, platelets also serves to strengthen the immune system. In the event of injury, the platelets gather at the wound and freezing so close the wound. Then, platelets directs bacteria to the spleen. Furthermore, bacteria are 'under siege' by dendritic cells that serve as cell endurance. So that's the immune response that kills bacteria.
Thrombocytopenia is a condition in which the number of platelets in the body has decreased and less than normal.
Symptoms of Thrombocytopenia:Bleeding can be a sign of skin beginning of the platelet count is less. Purplish spots often appear on the lower leg and minor injuries can cause bruising spread. Can bleeding gums and blood can also be found in the stool or urine. In female patients, menstrual blood very much. Bleeding may be difficult to stop so that surgery and accidents can be fatal.
If the platelet count goes down, the bleeding will get worse. Platelet count less than 5.000-10.000/mL can cause huge loss of blood through the digestive tract or brain bleeding that can be fatal.
Causes of ThrombocytopeniaSome things that cause thrombocytopenia are:
The bone marrow produces fewer platelets
- Aplastic Anemia
- Paroxysmal nocturnal hemoglobinuria
- Excessive alcohol use
- Megaloblastic Anemia
- Bone marrow disorders
Platelets trapped in the enlarged spleen
- Cirrhosis with congestive splenomegaly
- Gaucher Disease
Platelets become dissolved
- Replacement of massive blood transfusion or replace (because platelets can not survive in the blood transfused)
- Cardiopulmonary bypass surgery
Increasing the use or destruction of platelets
- Idiopathic thrombocytopenic purpura (ITP)
- HIV Infection
- Purpura after blood transfusion
- Drugs, such as heparin, kuinidin, quinine, sulfa-containing antibiotics, some oral diabetes medications, gold salt, rifampin
- Chronic Leukemia in newborn infants
- Systemic lupus erythematosus
- Circumstances involving clots in the blood vessels, such as obstetric complications, cancer, blood poisoning (septicemia) caused by gram-negative bacteria, traumatic brain damage
- Thrombotic thrombocytopenic purpura
- Hemolytic-uremic syndrome
- Adult respiratory distress syndrome
- Severe infection with septicemia.
To treat Thrombocytopenia, should be treated first cause of thrombocytopenia. Increasing levels of platelets in the blood will be effective if the cause is treated.